Description

1,3-Difluoro-5-Iodobenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor for functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoro-iodobenzene motif.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where halogenated aromatic rings are critical for bioactivity.
• Material Science Precursor: Serves as a monomer or starting material in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Sonogashira couplings, enabling the introduction of complex aryl groups.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.
• Ligand and Catalyst Development: Used to synthesize specialized ligands for metal complexes and catalysts used in asymmetric synthesis.

Basic Information

Product Name	1,3-Difluoro-5-Iodobenzene
CAS No.	2265-91-0
Molecular Formula	C6H3F2I
Molecular Weight	255.99 g/mol
Synonyms	5-Iodo-1,3-difluorobenzene; 3,5-Difluoroiodobenzene; 1-Iodo-3,5-difluorobenzene; m-Difluoro-m'-iodobenzene; Benzene, 1,3-difluoro-5-iodo-; 2265-91-0; 3,5-Difluorophenyl iodide
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-5-Iodobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.