Description

n-Demethyllincomycin is a key semi-synthetic intermediate derived from the natural antibiotic lincomycin. This compound is of significant value in pharmaceutical research and development, particularly for the synthesis of novel clindamycin analogs and other lincosamide antibiotics. It is primarily utilized by pharmaceutical manufacturers and R&D organizations focused on developing advanced antibacterial agents to address evolving microbial resistance.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of clindamycin and its derivatives.
• Antibacterial Research: Used in R&D for developing new lincosamide antibiotics with improved efficacy or spectrum.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs investigating the impact of molecular modifications on antibacterial activity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Used in studies targeting bacterial protein synthesis and ribosomal function.

Basic Information

Product Name	n-Demethyllincomycin
CAS No.	2256-16-8
Molecular Formula	C17H31N2O6S
Molecular Weight	391.51 g/mol
Synonyms	Lincomycin B; Demethyl lincomycin; N-Demethyl-lincomycin; (2S,4R)-N-[(1S,2S)-2-Hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide; U-24729A; Antibiotic U-24729A
EINECS	Contact for details

Quality Control

Our n-Demethyllincomycin is manufactured under strict quality systems to ensure high purity and consistency suitable for pharmaceutical R&D and intermediate synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.