Description

Tetrodotoxin CAS NO 2244-58-8 is a potent, naturally occurring neurotoxin that selectively blocks voltage-gated sodium channels in nerve and muscle cells. This high-purity compound is critical for advanced neuroscience research and pharmacological studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers for applications in neurophysiology, analgesic research, and as a precise biochemical tool.

Application

• Neuroscience Research: Used as a highly specific tool to block sodium channels, enabling the study of neuronal signaling, action potential generation, and synaptic transmission.
• Pharmacological Studies: Employed in the research and development of novel local anesthetics, analgesics, and drugs targeting ion channel pathologies.
• Physiological & Biochemical Assays: Serves as a critical reagent in assays designed to isolate and study sodium channel function in cell lines and tissue samples.
• Toxicology & Safety Testing: Used as a reference standard in analytical methods for the detection and quantification of marine and pufferfish toxins in food and environmental safety programs.
• Diagnostic Development: Acts as a key component in the development of immunoassays and biosensors for toxin detection.

Basic Information

Product Name	Tetrodotoxin
CAS No.	2244-58-8
Molecular Formula	C₁₁H₁₇N₃O₈
Molecular Weight	319.27 g/mol
Synonyms	TTX; Tetrodontoxin; Fugu Poison; Maculotoxin; Tarichatoxin; Spheroidine; Anhydrotetrodotoxin 4-epitetrodotoxin; Tetrodotoxin Citrate
EINECS	218-815-1

Quality Control

Our Tetrodotoxin is produced and handled under strict quality management protocols to ensure the highest standards of purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and safety data. We adhere to relevant guidelines for research-grade biochemicals to guarantee product integrity and reliable performance in sensitive experimental systems.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. This product is hygroscopic and should be handled in a controlled, dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Biological Activity	Confirmed by sodium channel blockade assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.