Description

2,6-Pyridinedicarboxylic Acid,4-(2-(2-Carboxy-2,3-Dihydro-5,6-Dihydroxy-1H-Indol-1-Yl)Ethenyl)-2,3-Dihydro-, (S-(R*,R))- is a complex, stereochemically defined heterocyclic compound that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its unique molecular architecture, featuring fused pyridine and indole moieties with multiple functional groups, makes it invaluable for constructing sophisticated pharmacophores and ligands. This high-purity intermediate is essential for research and development in pharmaceutical chemistry, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and for applications in asymmetric catalysis.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological and oncological pathways.
• Asymmetric Catalyst Ligand Synthesis: Used to develop novel chiral ligands for transition metal catalysis, enabling enantioselective transformations critical for producing single-isomer compounds.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing polycyclic and heterocyclic frameworks in medicinal chemistry and material science research.
• Biochemical Research: Potential use in designing enzyme inhibitors or probes due to its structural similarity to natural alkaloids and cofactors.
• Fine Chemical Production: Employed in the custom synthesis of high-value, specialty chemicals for contract research organizations (CROs) and development laboratories.

Basic Information

Product Name	2,6-Pyridinedicarboxylic Acid,4-(2-(2-Carboxy-2,3-Dihydro-5,6-Dihydroxy-1H-Indol-1-Yl)Ethenyl)-2,3-Dihydro-, (S-(R*,R))-
CAS No.	2181-76-2
Molecular Formula	C19H16N2O8
Molecular Weight	400.34 g/mol
Synonyms	(S-(R*,R*))-4-[2-(2-Carboxy-2,3-dihydro-5,6-dihydroxy-1H-indol-1-yl)ethenyl]-2,3-dihydro-2,6-pyridinedicarboxylic acid; L-6-Hydroxynorharman-α-carboxylic acid; Kyneurenic acid derivative; 4-(2-(2-Carboxy-2,3-dihydro-5,6-dihydroxy-1H-indol-1-yl)vinyl)-2,3-dihydro-2,6-pyridinedicarboxylic acid; (1S,2S)-1,2-Dihydroxy-1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid (related structure); A complex hydroxynorharman carboxylic acid.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment. We support compliance with ICH guidelines for impurity profiling and stability, catering to the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and may be hygroscopic; therefore, containers should be kept tightly sealed in a desiccated environment to maintain stability and purity. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.