Description

N'-Nitro-L-Arginine is a chemically modified derivative of the essential amino acid L-arginine, widely recognized as a potent and selective inhibitor of nitric oxide synthase (NOS). This compound is crucial for researchers and manufacturers in the life sciences sector, enabling precise control over nitric oxide signaling pathways in experimental and therapeutic contexts. It is primarily utilized by pharmaceutical R&D teams, biochemical suppliers, and academic institutions focused on cardiovascular, neurological, and immunological research.

Application

• Biochemical Research: As a standard nitric oxide synthase (NOS) inhibitor for studying NO-mediated signaling, vasodilation, and neurotransmission.
• Pharmaceutical Development: Serves as a key reference standard and intermediate in the development of therapeutics targeting conditions like hypertension, sepsis, and inflammation.
• Diagnostic Reagent Manufacturing: Used in the formulation of enzyme assay kits and diagnostic tests that measure NOS activity or nitric oxide levels.
• Academic & Clinical Studies: Employed in laboratory investigations to elucidate the role of nitric oxide in cellular processes, immune response, and disease models.
• Cell Culture & In Vitro Studies: Applied in controlled environments to modulate NO production for studying its effects on cell proliferation, apoptosis, and function.

Basic Information

Product Name	N'-Nitro-L-Arginine
CAS No.	2149-70-4
Molecular Formula	C6H13N5O4
Molecular Weight	219.20 g/mol
Synonyms	Nω-Nitro-L-arginine; L-Nω-Nitroarginine; NG-Nitro-L-arginine; NG-Nitro-L-arginine; L-NNA; NOLA; Nitroarginine; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid Nω-nitro-; N5-[Imino(nitroamino)methyl]-L-ornithine
EINECS	218-417-6

Quality Control

Our N'-Nitro-L-Arginine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term stability, consider storage under desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-24.0° to -28.0° (c=1 in 1N HCl)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.