Description

Vincristine Sulfate CAS NO 2068-78-2 is a potent vinca alkaloid derivative widely recognized as a critical chemotherapeutic agent. Its primary value lies in its ability to inhibit microtubule formation, arresting cell division in rapidly proliferating cells. This makes it an essential active pharmaceutical ingredient (API) for the formulation of injectable oncology treatments. It is primarily required by pharmaceutical manufacturers and research institutions focused on developing and producing cancer therapies.

Application

• Oncological Pharmaceutical Formulations: As a key active ingredient in injectable solutions for the treatment of various leukemias, lymphomas, and solid tumors.
• Clinical Research & Development: Used in preclinical and clinical studies to investigate new cancer treatment protocols and combination therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Biochemical Research: Utilized in cell biology studies to investigate mechanisms of mitosis, microtubule dynamics, and apoptosis.
• Generic Drug Manufacturing: A vital component for companies producing generic versions of established vincristine sulfate-based chemotherapy drugs.
• Veterinary Oncology: Applied in the development of chemotherapeutic treatments for certain cancers in animals.

Basic Information

Product Name	Vincristine Sulfate
CAS No.	2068-78-2
Molecular Formula	C46H56N4O10 · H2SO4
Molecular Weight	923.04 g/mol
Synonyms	Vincristine Sulphate; Leurocristine Sulfate; 22-Oxovincaleukoblastine Sulfate; Kyocristine; LCR; VCR; Oncovin; Vincasar PFS; (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate sulfate (1:1)
EINECS	218-190-0

Quality Control

Our Vincristine Sulfate is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical actives. Production adheres to current Good Manufacturing Practices (cGMP) guidelines. Each batch is subjected to comprehensive analytical testing, including identity, purity, and impurity profile verification via advanced techniques like HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive and hygroscopic (moisture-sensitive) nature, the product must be stored in its original packaging under controlled room temperature (15-25°C) or as specified on the label. Desiccants are recommended for long-term storage to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to slightly yellow, crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%
Specific Rotation	+15° to +25° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.