Description

6-Azauridine-5'-Monophosphate is a nucleotide analog of significant biochemical and pharmacological interest. This compound serves as a critical intermediate and research tool in the development of antiviral and anticancer agents, primarily due to its role as an inhibitor of orotidine monophosphate decarboxylase. It is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a potent inhibitor of orotidine 5'-monophosphate decarboxylase (OMP decarboxylase) in enzymatic studies and metabolic pathway analysis.
• Antiviral Agent Development: Serves as a precursor in research targeting viruses that are susceptible to nucleotide metabolism disruption.
• Cell Biology Studies: Employed to study pyrimidine biosynthesis and its role in cell proliferation and differentiation.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Enzyme Inhibition Assays: A critical reagent in high-throughput screening (HTS) for drug discovery programs targeting de novo pyrimidine synthesis.

Basic Information

Product Name	6-Azauridine-5'-Monophosphate
CAS No.	2018-19-1
Molecular Formula	C9H13N3O9P
Molecular Weight	338.19 g/mol
Synonyms	6-Azauridine 5'-Monophosphate; 6-Aza-UMP; 6-Azauridylic Acid; 2,4(1H,3H)-Pyrimidinedione, 3-β-D-ribofuranosyl-6-aza-, 5'-(dihydrogen phosphate); 6-Azuridine 5'-phosphate; 6-Azauridine 5'-phosphate disodium salt (related salt form); NSC 32074; Azauridine monophosphate
EINECS	Contact for details

Quality Control

Our 6-Azauridine-5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (Enzyme Assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.