Description

Valinomycin is a potent, naturally occurring cyclic dodecadepsipeptide antibiotic and ionophore, widely recognized for its high selectivity for potassium ions (K⁺). This compound is a critical research tool in biochemistry and physiology for studying mitochondrial function, membrane potential, and ion transport mechanisms. It is essential for researchers and manufacturers in the life sciences, pharmaceutical development, and agricultural chemistry sectors, where precise control of ionic gradients is required.

Application

• Biochemical Research: A gold standard potassium ionophore used to uncouple oxidative phosphorylation, induce apoptosis in studies, and probe the function of mitochondria and cell membranes.
• Pharmaceutical Development: Serves as a model compound for studying ion transport mechanisms and as a starting point for developing novel therapeutic agents targeting ion channels.
• Agricultural Chemistry: Investigated for its potential as a bioactive agent against certain fungi and bacteria, contributing to crop protection research.
• Biosensor & Diagnostic Kits: Used as a key component in ion-selective electrodes and diagnostic assays to calibrate and measure potassium ion activity.
• Cell Biology & Physiology: Employed to manipulate intracellular K⁺ concentrations and membrane potential in experimental cell cultures.
• Material Science: Studied for its incorporation into synthetic membranes and nano-devices for selective ion transport applications.

Basic Information

Product Name	Valinomycin
CAS No.	2001-95-8
Molecular Formula	C₅₄H₉₀N₆O₁₈
Molecular Weight	1111.32 g/mol
Synonyms	Antibiotic A 391; NSC 122023; Valinomycin A; Cyclo[(D-Val-L-Lac-L-Val-D-Hyi)₃]; L-Valinomycin; Potassium Ionophore I; K⁺ Ionophore; Miromycin
EINECS	217-896-6

Quality Control

Our Valinomycin is produced and tested under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Potassium Ionophore Activity	Confirmed by functional assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.