Description

Diphenyleneiodonium Chloride is a potent and selective inhibitor of flavin-containing enzymes, particularly NADPH oxidases. This unique mode of action makes it a critical research tool for studying reactive oxygen species (ROS) signaling pathways and oxidative stress in biological systems. It is primarily utilized by researchers and developers in the fields of biochemistry, pharmacology, and cell biology for mechanistic studies and drug discovery.

Application

• Biochemical Research: A key inhibitor for studying the role of NADPH oxidase (NOX) enzymes in cellular processes.
• Pharmacology & Drug Discovery: Used to investigate oxidative stress-related pathways as potential targets for therapeutic intervention in conditions like inflammation, neurodegeneration, and cardiovascular diseases.
• Cell Biology Studies: Employed to elucidate the signaling mechanisms of reactive oxygen species (ROS) in cell proliferation, apoptosis, and differentiation.
• Neuroscience Research: Applied in models to understand the contribution of oxidative stress to neuronal damage and neuroinflammatory diseases.
• Enzymology: Serves as a selective tool compound to inhibit flavin-dependent enzymes, aiding in the characterization of enzyme function and mechanism.

Basic Information

Product Name	Diphenyleneiodonium Chloride
CAS No.	244-54-2
Molecular Formula	C12H8ICl
Molecular Weight	314.55 g/mol
Synonyms	Diphenyleneiodonium chloride; DPI; 5H-Dibenzo[a,d]cyclohepten-5-one, 10,11-dihydro-5-iodo-; Iodonium, diphenylene-, chloride; 10,11-Dihydro-5-iododibenzo[a,d]cyclohepten-5-ium chloride; NSC 66311; CCRIS 7341
EINECS	Contact for details

Quality Control

Our Diphenyleneiodonium Chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.