Description

Prmt5-In-2 CAS NO 1989620-04-3 is a potent and selective small molecule inhibitor of the protein arginine methyltransferase 5 (PRMT5), a key epigenetic enzyme. This compound is critical for researchers and drug developers targeting cancers and other diseases driven by PRMT5 dysregulation. It is primarily utilized in pharmaceutical R&D for oncology target validation, high-throughput screening, and as a lead compound in the development of novel therapeutics.

Application

• Biochemical Research: Used as a selective tool compound to study PRMT5 enzyme kinetics, substrate specificity, and its role in cellular signaling pathways.
• Oncology Drug Discovery: Serves as a reference standard and lead molecule in the development of novel anti-cancer agents targeting PRMT5-dependent tumors.
• Epigenetics Studies: Employed to investigate the role of arginine methylation in gene expression, cell differentiation, and disease progression.
• High-Throughput Screening (HTS): Utilized as a positive control in assay development and screening campaigns to identify new PRMT5 inhibitors.
• Preclinical Development: Acts as a pharmacodynamic marker in animal models to evaluate target engagement and efficacy of PRMT5-targeting therapies.

Basic Information

Product Name	Prmt5-In-2
CAS No.	1989620-04-3
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	PRMT5-IN-2; PRMT5 Inhibitor 2; 1989620-04-3; 4-[[4-[[4-(1H-Pyrazol-1-yl)phenyl]amino]-5H-pyrrolo[3,2-d]pyrimidin-5-yl]methyl]benzonitrile; (5-{[4-(Cyanomethyl)phenyl]methyl}-4-{[4-(1H-pyrazol-1-yl)phenyl]amino}-5H-pyrrolo[3,2-d]pyrimidine)
EINECS	Contact for details

Quality Control

Our Prmt5-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity and relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.