Description

4-((4-Aminobutyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is a high-purity, functionalized isoindoline-1,3-dione derivative, a key structural motif in medicinal chemistry and advanced material science. This compound is specifically engineered for research and development applications requiring precise molecular scaffolds with reactive amine and imide functionalities. It serves as a critical building block for pharmaceutical researchers, agrochemical developers, and material scientists working on targeted drug discovery, polymer modification, and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted small-molecule therapeutics, particularly in oncology and immunology research.
• PROTAC (Proteolysis Targeting Chimera) Development: Serves as a versatile linker component connecting E3 ligase ligands (via the dioxopiperidine moiety) to target protein binders.
• Bioconjugation & ADC (Antibody-Drug Conjugate) Linker: The reactive primary amine group enables conjugation to antibodies, peptides, or other biomolecules for targeted delivery systems.
• Polymer & Material Science: Used as a functional monomer or cross-linking agent to introduce specific chemical properties into polymers, coatings, or advanced materials.
• Agrochemical Research: Employed in the development of novel active ingredients with specific biological activity.
• Chemical Biology Probe Synthesis: Facilitates the creation of molecular probes for studying protein function and cellular pathways.

Basic Information

Product Name	4-((4-Aminobutyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione
CAS No.	1957236-34-8
Molecular Formula	C17H21N5O4
Molecular Weight	359.38 g/mol
Synonyms	4-((4-Aminobutyl)amino)-2-(2,6-dioxo-3-piperidyl)isoindole-1,3-dione; 2-(2,6-Dioxopiperidin-3-yl)-4-[(4-aminobutyl)amino]-1H-isoindole-1,3(2H)-dione; 4-((4-Aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; PROTAC Linker 4; Aminobutyl-Dioxopiperidinyl Isoindolinedione; Thalidomide derivative with aminobutyl linker.
EINECS	Contact for details

Quality Control

Our 4-((4-Aminobutyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with research-grade specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.