Description

E3 Ligase Ligand-Linker Conjugates 14 (CAS No. 1957236-21-3) is a specialized bifunctional chemical probe designed for the targeted degradation of proteins via the PROTAC (PROteolysis TArgeting Chimera) technology platform. This compound is critical for advancing novel therapeutic strategies in drug discovery, enabling the precise elimination of disease-causing proteins that are traditionally considered "undruggable." It is an essential research tool for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and other areas of unmet medical need.

Application

• PROTAC Molecule Development: Serves as a key building block for constructing novel PROTACs to induce targeted protein degradation.
• Chemical Biology Research: Used as a molecular tool to study protein function, validate drug targets, and explore ubiquitin-proteasome system (UPS) pathways.
• Oncology Drug Discovery: Enables the degradation of oncogenic proteins and transcription factors in cancer cell lines and preclinical models.
• Neurological Disease Research: Applied in developing degraders for misfolded or aggregated proteins implicated in neurodegenerative conditions.
• E3 Ligase Engagement Studies: Facilitates the investigation of specific E3 ligase binding and recruitment efficiency for different target proteins.
• Structure-Activity Relationship (SAR) Optimization: Provides a core scaffold for medicinal chemistry efforts to improve the potency, selectivity, and pharmacokinetic properties of PROTAC candidates.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 14
CAS No.	1957236-21-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 14; E3 Ligase Recruiter 14; Targeted Protein Degradation Conjugate; Bifunctional Degradation Molecule; Ubiquitin Ligase Ligand-Linker; CRBN or VHL Ligand Derivative; Heterobifunctional Chemical Probe; PROTAC Intermediate 14
EINECS	Contact for details

Quality Control

Every batch of E3 Ligase Ligand-Linker Conjugates 14 is produced and analyzed under strict quality protocols to ensure consistency and reliability for sensitive research applications. Our products undergo rigorous purity verification using advanced analytical techniques, including HPLC and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored desiccated at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.