Description

Kn93 Hydrochloride is a potent and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII), a key enzyme involved in numerous cellular signaling pathways. This compound is essential for researchers investigating cardiac function, neuronal signaling, and other physiological processes where CaMKII activity plays a critical regulatory role. It is primarily utilized in biochemical research, pharmaceutical development, and academic studies focused on signal transduction and kinase biology.

Application

• Biochemical Research: A critical tool for studying the role of CaMKII in cellular signaling cascades, including calcium homeostasis and phosphorylation events.
• Cardiovascular Research: Used in models to investigate CaMKII's involvement in cardiac hypertrophy, arrhythmias, and heart failure.
• Neuroscience Studies: Applied to explore CaMKII function in synaptic plasticity, memory formation, and neuronal excitability.
• Pharmaceutical Screening: Serves as a reference compound in high-throughput screening assays for the discovery of novel CaMKII modulators.
• Cell Biology: Employed to dissect CaMKII-mediated pathways in cell proliferation, apoptosis, and gene expression.
• In Vitro Kinase Profiling: Used to assess selectivity and potency against CaMKII and related kinases in enzymatic assays.

Basic Information

Product Name	Kn93 Hydrochloride
CAS No.	1956426-56-4
Molecular Formula	C₂₀H₂₁ClN₂O₃ • HCl
Molecular Weight	409.31 g/mol
Synonyms	KN-93 hydrochloride; 2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine hydrochloride; CaMKII Inhibitor KN-93; KN 93 HCl; KN93 (hydrochloride); 4-[(2S)-2-[[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl](methyl)amino]-2-(4-hydroxy-3-methoxyphenyl)ethyl]benzenesulfonamide hydrochloride
EINECS	Contact for details

Quality Control

Our Kn93 Hydrochloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee product integrity and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.