Description

tert-Butyl 2,6-Difluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected carboxylic acid group and strategic fluorine substitutions, enabling precise molecular modifications for enhanced bioactivity and physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoronicotinate moiety contributes to efficacy and selectivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials and liquid crystals.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom chemical synthesis services catering to R&D and scale-up projects.

Basic Information

Item	Detail
Product Name	tert-Butyl 2,6-Difluoronicotinate
CAS No.	1956375-96-4
Molecular Formula	C10H11F2NO2
Molecular Weight	215.20 g/mol
Synonyms	2,6-Difluoropyridine-3-carboxylic acid tert-butyl ester; tert-Butyl 2,6-difluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2,6-difluoro-, 1,1-dimethylethyl ester; 2,6-Difluoro-3-pyridinecarboxylic acid tert-butyl ester; 1,1-Dimethylethyl 2,6-difluoro-3-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,6-Difluoronicotinate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.