Description

1H-Benzimidazole-5-Sulfonyl Chloride Hydrochloride is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. This compound is essential for introducing the benzimidazole-5-sulfonyl moiety into target molecules, enabling the development of novel compounds with specific functionalities. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of potential drug candidates, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting enzyme inhibition.
• Medicinal Chemistry Research: Used in high-throughput screening and the development of novel benzimidazole-based bioactive compounds.
• Agrochemical Synthesis: Building block for creating new herbicides, fungicides, and plant growth regulators.
• Material Science: Intermediate in the production of specialty polymers, dyes, and photoactive materials.
• Bioconjugation Chemistry: Reactive handle for modifying peptides, proteins, or other biomolecules via sulfonamide bond formation.
• Chemical Biology Probes: Used to develop molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Benzimidazole-5-Sulfonyl Chloride Hydrochloride
CAS No.	1956321-85-9
Molecular Formula	C7H6Cl2N2O2S
Molecular Weight	253.10 g/mol
Synonyms	Benzimidazole-5-sulfonyl chloride hydrochloride; 1H-Benzo[d]imidazole-5-sulfonyl chloride hydrochloride; 5-(Chlorosulfonyl)-1H-benzimidazole hydrochloride; 1H-Benzimidazole-5-sulfonic acid chloride hydrochloride; 5-Sulfonylchloride benzimidazole HCl; 5-Chlorosulfonyl-1H-benzimidazole hydrochloride; 1H-Benzoimidazole-5-sulfonyl chloride HCl
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-5-Sulfonyl Chloride Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.