Description

Ly3214996 is a potent and selective small molecule inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), a key regulator of the cell cycle. This compound is of significant interest for its role in targeted cancer research and therapeutic development, particularly in oncology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in the discovery of novel anti-cancer agents and the study of cell cycle dysregulation.

Application

• Oncology Research: A critical tool for investigating the role of CDK4/6 in tumor cell proliferation and for validating CDK4/6 as a therapeutic target in various cancer models.
• Drug Discovery & Development: Serves as a reference standard, lead compound, or pharmacologic probe in the development of next-generation CDK4/6 inhibitors.
• Biochemical Assays: Used in in vitro kinase inhibition studies to determine IC50 values and selectivity profiles against CDK4/6 and other kinases.
• Cell-Based Studies: Applied in cell culture experiments to induce cell cycle arrest (G1 phase) and study downstream signaling pathways in cancer cell lines.
• Preclinical Studies: Employed in animal models of cancer to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of CDK4/6 inhibition.
• Mechanism of Action (MoA) Studies: Essential for elucidating the complex mechanisms of cell cycle control and resistance pathways to CDK4/6-targeted therapies.

Basic Information

Item	Detail
Product Name	Ly3214996
CAS No.	1951483-29-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LY-3214996; LY3214996; 1951483-29-6; CDK4/6 Inhibitor LY3214996; (S)-LY3214996; (S)-N-(5-((4-(4-(ethylsulfonyl)piperazin-1-yl)pyrimidin-2-yl)amino)-2-methylphenyl)-4-(4-methyl-3-(methylsulfonyl)phenyl)-3,6-dihydropyridine-1(2H)-carboxamide
EINECS	Contact for details

Quality Control

Our Ly3214996 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and strength is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and must be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.