Description

Bis((5-Fluoropyridin-3-Yl)Methyl)Amine Hydrochloride is a high-purity, fluorinated pyridine derivative building block essential for advanced pharmaceutical and agrochemical research. This compound serves as a critical intermediate in the synthesis of novel active ingredients, particularly for targeted therapies and crop protection agents. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique fluorinated heterocyclic structure into new molecular entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in kinase inhibitor and central nervous system (CNS) targeted research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides where the fluoropyridine moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with specific electronic or photophysical properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways due to its fluorine atom, which can act as an isostere.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	Bis((5-Fluoropyridin-3-Yl)Methyl)Amine Hydrochloride
CAS No.	1951439-24-9
Molecular Formula	C13H12F2N3•HCl
Molecular Weight	287.71 g/mol (Free base: 251.26 g/mol)
Synonyms	N,N-Bis((5-Fluoropyridin-3-yl)methyl)amine hydrochloride; 3,3'-(Aminomethylene)bis(5-fluoropyridine) hydrochloride; 5-Fluoro-3-[[[(5-fluoro-3-pyridinyl)methyl]amino]methyl]pyridine hydrochloride; Bis(5-fluoro-3-pyridylmethyl)amine HCl; 1,1'-(5-Fluoropyridine-3,3-diyl)bis(N-methylmethanamine) hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results for assay, impurities, and other critical parameters are available upon request. We adhere to cGMP principles for the manufacture of advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.