Description

E3 Ligase Ligand-Linker Conjugates 20 is a high-purity, synthetic chemical compound designed for advanced pharmaceutical research and development. This compound serves as a critical component in the construction of Proteolysis-Targeting Chimeras (PROTACs), a revolutionary therapeutic modality for targeted protein degradation. It is essential for researchers and organizations in the fields of oncology, neurodegenerative disease, and drug discovery who require reliable, high-quality building blocks for novel degrader development. The product is supplied with full analytical characterization to ensure batch-to-batch consistency for your critical experiments.

Application

• PROTAC (Proteolysis-Targeting Chimera) Development: Serves as a key ligand-linker component for recruiting E3 ubiquitin ligases to facilitate the targeted degradation of disease-causing proteins.
• Bifunctional Molecule Synthesis: Used as a precise chemical handle for conjugating target protein ligands to E3 ligase ligands, enabling the creation of new molecular entities.
• Chemical Biology Research: Employed in studies investigating ubiquitin-proteasome system (UPS) pathways and mechanisms of induced protein degradation.
• Preclinical Drug Discovery: Integral for the synthesis and optimization of candidate degrader molecules in early-stage therapeutic programs.
• Oncology & Immunology Target Validation: Facilitates the exploration of "undruggable" targets by enabling their selective removal within cellular models.
• Academic & Institutional Research: Provides a reliable reagent for laboratories focused on novel therapeutic strategies and molecular tool development.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 20
CAS No.	1950635-15-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker 20; E3 Ligase Ligand Conjugate 20; Cereblon Ligand-Linker Conjugate; Thalidomide-based PROTAC Linker; (S,R,S)-AHPC-PEG3-C2-NH2 derivative; Molecular Glue Component; Targeted Protein Degradation Reagent; Bifunctional Degrader Building Block
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 20 is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical R&D. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines for advanced intermediates, and our quality protocols are designed to support regulatory filings. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a desiccated environment to prevent moisture absorption. For long-term storage, maintain at -80°C. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure to humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.