Description

E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate is a high-purity, synthetic chemical building block specifically designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) modalities. This compound serves as a critical component for linking an E3 ubiquitin ligase-recruiting ligand to a target protein-binding warhead, enabling the precise hijacking of the cell's natural protein degradation machinery. It is essential for researchers and developers in pharmaceutical R&D, biotechnology, and academic institutions focused on creating novel therapeutics for oncology, neurodegenerative diseases, and other challenging targets.

Application

• Core Component for PROTAC Synthesis: Serves as the essential linker-ligand conjugate for constructing bifunctional PROTAC molecules that degrade specific disease-causing proteins.
• Targeted Protein Degradation (TPD) Research: Enables fundamental and applied research in the field of induced protein degradation for "undruggable" targets.
• Oncology Drug Discovery: Used in the development of novel cancer therapies aimed at degrading oncoproteins, transcription factors, or other key survival proteins in tumor cells.
• Neurological Disease Research: Applied in creating degraders for misfolded or aggregated proteins implicated in conditions like Alzheimer's, Parkinson's, and Huntington's disease.
• Chemical Biology Tool Development: Utilized to create molecular probes for studying protein function, ubiquitin-proteasome system (UPS) dynamics, and cellular signaling pathways.
• Preclinical Candidate Optimization: Employed during the medicinal chemistry phase to optimize the pharmacokinetics, cell permeability, and degradation efficiency of lead TPD compounds.

Basic Information

Item	Details
Product Name	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
CAS No.	1950635-14-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker-Ligand Conjugate 25 TFA; E3 Ligase Recruiting Moiety-Linker 25; VHL Ligand-Linker Conjugate 25 Trifluoroacetate Salt; (S,R,S)-AHPC-C5-O-C5-O-C5-OH TFA; Degrader Building Block 25; TPD Linker 25; Targeted Degradation Tool Compound 25
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, which is critical for sensitive biological applications. All batches are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.