Description

3-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester is a high-value fluorinated pyridine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its structure, featuring both a fluorine substituent and a tert-butyl ester protecting group, makes it indispensable for constructing complex molecules with precise regiochemistry. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of novel fluorinated polymers and liquid crystals with unique electronic and optical properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester
CAS No.	1934827-83-4
Molecular Formula	C10H12FNO2
Molecular Weight	197.21 g/mol
Synonyms	tert-Butyl 3-fluoropyridine-2-carboxylate; 3-Fluoro-2-pyridinecarboxylic acid 1,1-dimethylethyl ester; 2-Pyridinecarboxylic acid, 3-fluoro-, 1,1-dimethylethyl ester; 3-Fluoro-2-(tert-butoxycarbonyl)pyridine; 3-Fluoropicolinic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Fluoropyridine-2-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting purity, impurity profiles, and physical data. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.