Description

([Ring-D5]Phe6)-Somatostatin-14 is a deuterium-labeled analog of the endogenous cyclic tetradecapeptide hormone, somatostatin-14. This stable isotope-labeled compound is critical for use as an internal standard in quantitative mass spectrometry-based bioanalytical assays, ensuring high accuracy and reproducibility. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors, particularly for pharmacokinetic studies, metabolic profiling, and peptide quantification.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of native somatostatin-14 in biological matrices.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of peptide drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Metabolomics & Biomarker Research: Used in targeted proteomic and peptidomic studies to investigate disease mechanisms and discover novel biomarkers.
• Pharmaceutical Quality Control: Supports assay validation, method development, and batch testing for peptide-based therapeutics to ensure product consistency and safety.
• Endocrinology Research: Facilitates the study of somatostatin's role in regulating hormone secretion (growth hormone, insulin, glucagon) and cell proliferation.
• GMP/GLP-Compliant Analysis: Essential for regulatory submissions and compliant laboratory work requiring traceable and characterized reference materials.

Basic Information

Item	Details
Product Name	([Ring-D5]Phe6)-Somatostatin-14
CAS No.	1926163-72-5
Molecular Formula	C76H99D5N18O19S2
Molecular Weight	~1639.9 g/mol (deuterated form)
Synonyms	Somatostatin-14 (Phe6-D5); Deuterated Somatostatin-14; Ala-Gly-Cys-Lys-Asn-Phe([D5])-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys (cyclic 3-14 disulfide); SRIF-14 (D5-Phe6); Growth Hormone Release-Inhibiting Hormone (D5 analog); Stable Isotope-Labeled Somatostatin; SST-14 (D5); Internal Standard for Somatostatin-14.
EINECS	Contact for details

Quality Control

Our ([Ring-D5]Phe6)-Somatostatin-14 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity and isotopic enrichment verification, and amino acid analysis. Certificates of Analysis (COA) detailing batch-specific results for purity, isotopic purity, water content, and peptide content are provided. The material is suitable for use in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC-MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Isotopic Purity (D5)	≥ 98 atom % D
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	Reported on COA
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.