Description

Z-Val-Glu(Ome)-Ile-Dl-Asp(Ome)-Fluoromethylketone is a specialized fluoromethyl ketone-based peptide inhibitor designed for targeted protease activity modulation. This compound is a critical research tool for studying caspase and other protease functions in programmed cell death (apoptosis) pathways. It is primarily utilized by pharmaceutical R&D teams and academic researchers in the fields of biochemistry, oncology, and neurobiology for developing novel therapeutic strategies.

Application

• Biochemical Research: A potent and selective inhibitor for studying the activity and inhibition mechanisms of specific caspases and serine proteases in vitro.
• Apoptosis Pathway Analysis: Used in cell-based assays to investigate the role of specific proteases in apoptotic signaling cascades, helping to map disease mechanisms.
• Drug Discovery & Development: Serves as a key pharmacophore or lead compound in the design and screening of new therapeutic agents targeting inflammatory and degenerative diseases.
• Enzyme Kinetics Studies: Employed to determine kinetic parameters (e.g., Ki, IC50) for target proteases, providing essential data for understanding enzyme-inhibitor interactions.
• Neuroscience Research: Applied in models of neurological disorders to probe the involvement of protease-mediated pathways in conditions like stroke and Alzheimer's disease.
• Oncology Research: Used to induce or inhibit apoptosis in cancer cell lines, aiding in the evaluation of potential chemotherapeutic targets and resistance mechanisms.

Basic Information

Product Name	Z-Val-Glu(Ome)-Ile-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	1926163-62-3
Molecular Formula	C30H43FN4O10
Molecular Weight	638.69 g/mol
Synonyms	Z-VEID-FMK; Z-Val-Glu(OMe)-Ile-Asp(OMe)-FMK; Caspase-6 Inhibitor Z-VEID-FMK; Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethyl ketone; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[(Benzyloxycarbonyl)amino]-3-methylpentanoyl]amino]-4-methoxy-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-5-[(2-fluoroacetyl)amino]-5-oxopentanoyl]amino]pentanedioic acid dimethyl ester; Ac-DEVD-FMK analog; Fluoromethyl ketone peptide inhibitor VEID
EINECS	Contact for details

Quality Control

Our Z-Val-Glu(Ome)-Ile-Dl-Asp(Ome)-Fluoromethylketone is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing including HPLC for purity assessment and MS and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.