Description

Z-Val-Asp(Ome)-Val-Ala-Dl-Asp(Ome)-Fluoromethylketone is a specialized fluoromethyl ketone-based peptide inhibitor designed for targeted protease activity modulation. This compound is of significant value in biochemical research for its role as a potent and selective caspase inhibitor, crucial for studying programmed cell death pathways. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on apoptosis research, neuroprotection studies, and inflammatory disease models.

Application

• Biochemical Research: Used as a key reagent in enzymatic assays to study the kinetics and inhibition profiles of specific caspases.
• Apoptosis Studies: Essential for in vitro and cell-based experiments to inhibit caspase activity and elucidate cell death mechanisms.
• Neurodegenerative Disease Research: Applied in models of stroke, Alzheimer's, and Parkinson's disease to investigate the role of caspases in neuronal loss.
• Inflammation and Immunology: Utilized to probe the involvement of caspases in inflammatory signaling pathways and immune cell regulation.
• Drug Discovery Screening: Serves as a reference compound or positive control in high-throughput screening for novel caspase inhibitor therapeutics.
• Ischemia-Reperfusion Injury Models: Employed in research exploring therapeutic interventions for tissue damage following heart attack or stroke.

Basic Information

Product Name	Z-Val-Asp(Ome)-Val-Ala-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	1926163-61-2
Molecular Formula	C31H45FN4O11
Molecular Weight	668.71 g/mol
Synonyms	Z-VDVAD-FMK; Caspase-2 Inhibitor Z-VDVAD-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK; Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; Caspase 2 Inhibitor II; (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-(Benzyloxycarbonylamino)-3-methylbutanoyl]amino]-3-methoxy-3-oxopropanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-4-fluoro-3-methoxy-4-oxobutanoic Acid
EINECS	Contact for details

Quality Control

Our Z-Val-Asp(Ome)-Val-Ala-Dl-Asp(Ome)-Fluoromethylketone is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive research applications. All products undergo rigorous analytical testing, including HPLC, MS, and NMR, to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.