Description

Z-Ile-Glu(Ome)-Thr-Dl-Asp(Ome)-Fluoromethylketone is a specialized fluoromethylketone-based peptide inhibitor designed for targeted protease activity modulation. This compound is of significant value in biochemical research for its role as a potent and selective inhibitor of specific cysteine proteases, including caspases, which are critical in apoptosis studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for inflammatory and neurodegenerative diseases.

Application

• Biochemical Research: Used as a key tool compound for studying the mechanisms of apoptosis (programmed cell death) and inflammation.
• Pharmaceutical Development: Serves as a lead structure or reference standard in the discovery and optimization of caspase inhibitor drugs.
• Enzyme Kinetics: Employed in in vitro assays to determine the activity and inhibition constants (Ki) of target proteases.
• Cell Biology Studies: Applied in cell culture models to investigate caspase-dependent signaling pathways and validate drug targets.
• Proteomics: Utilized in activity-based protein profiling (ABPP) to identify and characterize active protease families in complex biological samples.
• Reference Standard: Acts as a high-purity analytical standard for quality control in related inhibitor synthesis and for method development in analytical laboratories.

Basic Information

Product Name	Z-Ile-Glu(Ome)-Thr-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	1926163-59-8
Molecular Formula	C30H43FN4O11
Molecular Weight	630.68 g/mol
Synonyms	Z-IETD-FMK; Caspase-8 Inhibitor II; Z-Ile-Glu-Thr-Asp-Fluoromethylketone; Z-IETD-FMK Caspase Inhibitor; Benzyloxycarbonyl-Ile-Glu-Thr-Asp-fluoromethyl ketone; Ac-DEVD-FMK (structural analog); Caspase-8 Inhibitor, Z-IETD-FMK; Fluoromethyl ketone peptide inhibitor Z-IETD
EINECS	Contact for details

Quality Control

Our Z-Ile-Glu(Ome)-Thr-Dl-Asp(Ome)-Fluoromethylketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and NMR for structural validation. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade standards. We support custom synthesis to meet specific purity and packaging requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.