Description

Z-Asp(Ome)-Gln-Met-Dl-Asp(Ome)-Fluoromethylketone CAS NO 1926163-58-7 is a specialized, high-purity fluoromethyl ketone peptide derivative designed as a potent and selective protease inhibitor. This compound is critical for researchers and developers in the life sciences sector, providing a precise biochemical tool for studying enzyme mechanisms and signaling pathways. It is primarily utilized by pharmaceutical R&D teams and academic laboratories focused on drug discovery, particularly in the development of novel therapeutics targeting proteolytic enzymes.

Application

• Protease Inhibition Research: Serves as a key biochemical tool for studying the activity and inhibition mechanisms of specific cysteine or serine proteases in vitro.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays and hit-to-lead optimization programs to develop new therapeutic agents.
• Apoptosis (Programmed Cell Death) Studies: Employed in cellular and molecular biology research to investigate caspase-mediated apoptotic pathways.
• Biochemical Assay Development: Acts as a reference standard or active control in developing and validating enzymatic activity assays.
• Inflammatory Disease Research: Applied in models studying diseases where dysregulated protease activity is implicated, such as arthritis or neurodegenerative conditions.
• Academic & Institutional Research: Supports fundamental research in university and government laboratories exploring protein biochemistry and enzymology.

Basic Information

Product Name	Z-Asp(Ome)-Gln-Met-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	1926163-58-7
Molecular Formula	C31H44FN5O11S
Molecular Weight	705.77 g/mol
Synonyms	Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK; Z-DEVD-FMK (alternative sequence analog); Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethyl ketone; Caspase-3 Inhibitor VI (contextual); Ac-DEVD-CHO fluoromethyl ketone derivative; Peptidyl fluoromethyl ketone inhibitor; Z-Asp(OMe)-Gln-Met-D-Asp(OMe)-FMK; Z-Asp(OMe)-Gln-Met-L-Asp(OMe)-FMK (DL mixture)
EINECS	Contact for details

Quality Control

Every batch of Z-Asp(Ome)-Gln-Met-Dl-Asp(Ome)-Fluoromethylketone is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA), providing batch-specific data from techniques including HPLC, MS, and NMR, is available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.