Description

Z-Tyr-Val-Ala-Dl-Asp-Fluoromethylketone is a potent and selective fluoromethyl ketone-based caspase inhibitor, widely recognized in biochemical research. This compound is crucial for studying apoptotic pathways and the role of specific caspases in cellular processes. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies focused on developing novel therapeutics for conditions involving dysregulated apoptosis, such as neurodegenerative diseases and cancer.

Application

• Biochemical Research: A key tool for investigating the mechanisms and regulation of apoptosis (programmed cell death).
• Pharmaceutical Development: Used in target validation and screening assays for drug discovery programs targeting caspase-mediated diseases.
• Enzyme Inhibition Studies: Serves as a specific inhibitor to characterize the activity and substrate specificity of various caspase enzymes.
• Neurodegenerative Disease Research: Applied in models of Alzheimer's, Parkinson's, and stroke to understand the role of caspases in neuronal cell death.
• Oncology Research: Utilized to study the evasion of apoptosis in cancer cells and to evaluate potential pro-apoptotic anti-cancer agents.
• Inflammatory Pathway Analysis: Employed in immunology research to dissect caspase-1 involvement in pyroptosis and inflammation.

Basic Information

Product Name	Z-Tyr-Val-Ala-Dl-Asp-Fluoromethylketone
CAS No.	1926163-56-5
Molecular Formula	C30H39FN4O9
Molecular Weight	618.65 g/mol
Synonyms	Z-YVAD-FMK; Z-Tyr-Val-Ala-Asp-FMK; Caspase-1 Inhibitor IV; Ac-YVAD-CMK; Z-YVAD-Fluoromethyl Ketone; Z-Tyr-Val-Ala-Asp(OMe)-FMK; (Benzyloxycarbonyl)-Tyr-Val-Ala-Asp-fluoromethyl ketone; Caspase Inhibitor, YVAD
EINECS	Contact for details

Quality Control

Our Z-Tyr-Val-Ala-Dl-Asp-Fluoromethylketone is manufactured under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all quality parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.