Description

Ptp1B-In-2 is a potent and selective small-molecule inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), a key enzyme involved in insulin and leptin signaling pathways. This compound is a critical research tool for investigating metabolic disorders such as type 2 diabetes and obesity, offering high specificity to minimize off-target effects. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in metabolic disease research, drug discovery, and biochemical pathway analysis.

Application

• Biochemical Research: Used as a selective probe to study the role of PTP1B in insulin receptor and leptin signaling cascades.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening (HTS) campaigns for novel anti-diabetic and anti-obesity therapeutics.
• Academic Studies: Facilitates in vitro and cellular research into metabolic regulation, insulin resistance, and potential therapeutic interventions.
• Target Validation: Employed to validate PTP1B as a pharmacological target in various disease models.
• Enzyme Kinetics: Used in assays to determine inhibition constants (IC50/Ki) and study enzyme mechanism-of-action.

Basic Information

Product Name	Ptp1B-In-2
CAS No.	1919853-46-5
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	PTP1B Inhibitor 2; 4-[(3,5-Dimethyl-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(4-fluorophenyl)benzamide; BML-SI306-0025; PTP1B-IN-2; Thieno[2,3-d]pyrimidine-based PTP1B inhibitor; Protein Tyrosine Phosphatase 1B Inhibitor II
EINECS	Contact for details

Quality Control

Our Ptp1B-In-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.