Description

Kn-93 (Phosphate) is a potent and selective cell-permeable inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). This compound matters for researchers as it provides a critical tool for elucidating the role of CaMKII in cellular signaling pathways, including those involved in cardiac function, neuronal plasticity, and memory formation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, cardiology, and signal transduction research.

Application

• Biochemical Research: A key pharmacological tool for studying CaMKII-dependent signaling cascades in vitro and in cell-based assays.
• Neuroscience Studies: Investigation of CaMKII's role in synaptic plasticity, long-term potentiation (LTP), and memory-related processes.
• Cardiovascular Research: Exploration of CaMKII function in cardiac myocyte excitation-contraction coupling, arrhythmogenesis, and heart failure models.
• Drug Discovery: Used as a reference compound in high-throughput screening and target validation for therapeutic programs targeting CaMKII.
• Cellular Physiology: Probing the involvement of CaMKII in hormone secretion, gene expression, and cell cycle regulation.

Basic Information

Product Name	Kn-93 (Phosphate)
CAS No.	1913269-12-1
Molecular Formula	C₂₄H₂₈N₄O₈P₂
Molecular Weight	562.45 g/mol
Synonyms	KN-93 phosphate; 2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine phosphate; CaMKII Inhibitor KN-93 (phosphate salt); KN93 phosphate; N-[2-[[[(2E)-3-(4-Chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate
EINECS	Contact for details

Quality Control

Our Kn-93 (Phosphate) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications for identity, purity, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.