Description

Pi3Kδ-In-1 is a potent and selective small-molecule inhibitor of the phosphoinositide 3-kinase delta (PI3Kδ) isoform, a key signaling node in immune cell function. This compound matters for researchers and developers as it provides a critical tool for investigating the role of PI3Kδ in inflammatory and autoimmune diseases, as well as in certain hematological malignancies. Pharmaceutical R&D teams and academic institutions focused on immunology and oncology are the primary users, leveraging it for target validation, mechanism-of-action studies, and early-stage drug discovery programs.

Application

• Biochemical Research: Used as a reference standard and pharmacological tool to selectively inhibit PI3Kδ activity in in vitro enzyme and cell-based assays.
• Immunology Studies: Investigates the role of PI3Kδ signaling in B-cell and T-cell activation, proliferation, and survival, relevant to autoimmune conditions.
• Oncology Research: Explores the therapeutic potential of PI3Kδ inhibition in B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma.
• Inflammatory Disease Models: Applied in preclinical research for conditions like rheumatoid arthritis, asthma, and allergic responses where PI3Kδ is implicated.
• Drug Discovery & Development: Serves as a lead compound or benchmark for the design and optimization of novel PI3Kδ-targeted therapeutics.
• Signal Transduction Pathway Analysis: Aids in mapping downstream effectors of the PI3K/AKT/mTOR pathway in specific immune cell contexts.

Basic Information

Product Name	Pi3Kδ-In-1
CAS No.	1911564-39-0
Molecular Formula	C₂₆H₂₈N₈O₂
Molecular Weight	484.56 g/mol
Synonyms	PI3Kδ Inhibitor 1; (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one; 5-Chloro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)ethyl]-3,4-dihydroquinazolin-4-one; PI3K delta Inhibitor; PI3Kδ-In-1; 1911564-39-0; CHEMBL2103875; HY-101877
EINECS	Contact for details

Quality Control

Our Pi3Kδ-In-1 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with each shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.