Description

(R)-1-(5-Fluoropyridin-3-Yl)Ethanamine Dihydrochloride CAS NO 1909288-54-5 is a high-purity chiral amine derivative, specifically the dihydrochloride salt of the (R)-enantiomer, featuring a fluoropyridine moiety. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, where its defined stereochemistry and functional groups are essential for creating molecules with specific biological activity. It is primarily required by pharmaceutical R&D and fine chemical synthesis teams for developing active pharmaceutical ingredients (APIs), agrochemicals, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly in kinase inhibitors and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used as a building block for creating advanced, enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Research: Acts as a probe or precursor in the study of biological pathways and enzyme interactions due to its fluorinated pyridine structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions.
• Academic Research: Utilized in university and institutional laboratories for methodological studies in organic chemistry and medicinal chemistry.

Basic Information

Product Name	(R)-1-(5-Fluoropyridin-3-Yl)Ethanamine Dihydrochloride
CAS No.	1909288-54-5
Molecular Formula	C7H11Cl2FN2
Molecular Weight	213.08 g/mol
Synonyms	(R)-1-(5-Fluoropyridin-3-yl)ethan-1-amine dihydrochloride; (R)-1-(5-Fluoro-3-pyridinyl)ethylamine dihydrochloride; (R)-α-Methyl-5-fluoronicotinamide dihydrochloride (precursor name); (R)-5-Fluoro-3-(1-aminoethyl)pyridine dihydrochloride; (R)-Enantiomer of 1-(5-Fluoropyridin-3-yl)ethanamine dihydrochloride; (R)-FEAD hydrochloride; (R)-FEAD·2HCl
EINECS	Contact for details

Quality Control

Our (R)-1-(5-Fluoropyridin-3-Yl)Ethanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including chiral purity verification by HPLC to ensure enantiomeric excess (ee) meets client specifications. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data, and our production can be aligned with ICH guidelines for pharmaceutical development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.