Description

Kdm5A-In-1 is a potent and selective small-molecule inhibitor of the KDM5A (JARID1A) histone demethylase, a key epigenetic regulator. This compound is crucial for researchers investigating chromatin remodeling, gene expression, and the role of histone modifications in cellular processes like differentiation and oncogenesis. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology companies focused on oncology, neurobiology, and epigenetic drug discovery.

Application

• Epigenetics Research: Used as a selective chemical probe to study the biological function and inhibition of the KDM5/JARID1 family of histone demethylases.
• Oncology Studies: Investigated in cancer research for its potential to modulate gene expression programs involved in tumor progression, drug resistance, and cell proliferation.
• Stem Cell & Developmental Biology: Applied in studies of cellular differentiation, pluripotency, and development where precise control of histone methylation is critical.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assay development and screening campaigns for novel epigenetic modulators.
• Biochemical Assay Development: Utilized to establish and validate in vitro enzymatic assays for KDM5A and related demethylases.
• Mechanism of Action Studies: Employed to elucidate downstream signaling pathways and transcriptional networks regulated by KDM5A activity.

Basic Information

Item	Detail
Product Name	Kdm5A-In-1
CAS No.	1905481-36-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	KDM5A Inhibitor 1; JARID1A Inhibitor; KDM5A-IN-1; KDM5 Inhibitor; Histone Demethylase KDM5A Inhibitor; (S)-2-(4-(4-Chlorophenoxy)phenyl)-1-(1H-imidazol-1-yl)-3-(piperidin-1-yl)propan-2-ol (IUPAC-based); 1905481-36-8
EINECS	Contact for details

Quality Control

Our Kdm5A-In-1 is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.