Description

Pde1-In-2 is a potent and selective small molecule inhibitor of phosphodiesterase 1 (PDE1), a key enzyme involved in cellular signaling pathways. This high-purity compound is essential for researchers and developers in the life sciences sector, providing a critical tool for modulating cyclic nucleotide levels and studying related physiological processes. It is primarily utilized in pharmaceutical R&D for target validation, mechanism of action studies, and as a lead compound in the development of novel therapeutics for neurological and cardiovascular conditions.

Application

• Pharmaceutical Research & Development: Serves as a key biochemical tool for target validation and lead optimization in drug discovery programs targeting PDE1.
• Mechanistic Studies: Used in vitro and in vivo to investigate the role of PDE1 in cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) signaling cascades.
• Neurological Disorder Research: Applied in preclinical models to study potential therapeutic applications for cognitive disorders, neurodegenerative diseases, and neuropsychiatric conditions.
• Cardiovascular Research: Utilized to explore the effects of PDE1 inhibition on vascular tone, cardiac function, and related pathologies.
• Biochemical Assay Development: Acts as a reference standard and positive control in high-throughput screening (HTS) assays and enzymatic activity tests.
• Academic Research: Supports fundamental biological research in universities and institutes focusing on cell signaling and enzymology.

Basic Information

Product Name	Pde1-In-2
CAS No.	1904611-63-7
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	PDE1-IN-2; PDE1 Inhibitor 2; 6-(4-(Diethylamino)phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one; 6-[4-(Diethylamino)phenyl]-5-methyl-4,5-dihydro-2H-pyridazin-3-one; 1904611-63-7; PDE1i-2
EINECS	Contact for details

Quality Control

Our Pde1-In-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We adhere to cGMP guidelines for the production of non-GMP materials intended for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.