Description

1-(1,1-Difluoro-2-Methylpropyl)-3-Methyl- Benzene is a specialized fluorinated aromatic compound that serves as a high-value building block in advanced organic synthesis. Its unique structure, featuring a gem-difluoroalkyl side chain, is critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides and pesticides, where the difluoro moiety can enhance biological activity and environmental persistence profiles.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and liquid crystals with tailored electronic or surface properties.
• Fluorine Chemistry: An essential reagent for introducing the (1,1-difluoro-2-methylpropyl) group into complex organic molecules via cross-coupling or addition reactions.
• Contract Research & Manufacturing (CRAM): Supplied to custom synthesis organizations for use in client-directed projects requiring advanced fluorinated intermediates.

Basic Information

Product Name	1-(1,1-Difluoro-2-Methylpropyl)-3-Methyl- Benzene
CAS No.	1897681-51-4
Molecular Formula	C12H16F2
Molecular Weight	198.25 g/mol
Synonyms	3-Methyl-1-(1,1-difluoro-2-methylpropyl)benzene; 1-(1,1-Difluoro-2-methylpropyl)-3-methylbenzene; m-Xylene, 1-(1,1-difluoro-2-methylpropyl)-; (3-Methylphenyl)(1,1-difluoro-2-methylpropyl); α,α-Difluoro-3-methylcumene; 1-(1,1-Difluoro-2-methylpropyl)-3-methyl-benzene; Benzene, 1-(1,1-difluoro-2-methylpropyl)-3-methyl-
EINECS	Contact for details

Quality Control

Our production of 1-(1,1-Difluoro-2-Methylpropyl)-3-Methyl- Benzene adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, NMR, and GC-MS for comprehensive characterization and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.