Description

A-485 CAS NO 1889279-16-6 is a potent and selective small molecule inhibitor of the p300/CBP histone acetyltransferases (HATs). This compound matters as a critical research tool for epigenetics and oncology studies, enabling precise modulation of gene expression and cellular signaling pathways. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for cancer, inflammatory diseases, and neurological disorders.

Application

• Epigenetics Research: Used as a selective chemical probe to investigate the biological roles of p300/CBP-mediated histone acetylation in chromatin remodeling and transcriptional regulation.
• Oncology Studies: Employed in vitro and in vivo to study tumor growth, proliferation, and survival pathways dependent on p300/CBP HAT activity, aiding in target validation for cancer therapy.
• Drug Discovery: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for developing novel HAT inhibitors.
• Cellular Pathway Analysis: Utilized to dissect signaling cascades in immune cells, stem cells, and neurons, helping to elucidate mechanisms in inflammation and neurobiology.
• Biochemical Assays: Acts as a key reagent in enzymatic assays to measure p300/CBP inhibition and evaluate compound potency and selectivity.

Basic Information

Product Name	A-485
CAS No.	1889279-16-6
Molecular Formula	C30H31N5O5S
Molecular Weight	573.66 g/mol
Synonyms	A-485; A485; (1R,4R)-N-[(1S)-1-[5-[(2,3-Dihydro-1,4-benzodioxin-6-yl)sulfonyl]-2-methoxyphenyl]ethyl]-6-oxa-3-azabicyclo[3.2.1]octane-4-carboxamide; p300/CBP HAT Inhibitor A-485; EP300/CREBBP Inhibitor A-485; Histone Acetyltransferase p300/CBP Inhibitor A-485
EINECS	Contact for details

Quality Control

Our A-485 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.