Description

Erk5-In-2 is a potent and selective small-molecule inhibitor of Extracellular signal-Regulated Kinase 5 (ERK5), a key signaling node in cellular proliferation and survival pathways. This compound is a critical research tool for elucidating the complex biological roles of ERK5 in oncology, inflammation, and cardiovascular disease. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in kinase-targeted drug discovery and signal transduction research.

Application

• Biomedical Research: A fundamental tool for studying ERK5/MAPK7 signaling pathways in cellular and animal models.
• Oncology Research: Used to investigate the role of ERK5 in cancer cell proliferation, survival, and metastasis, supporting target validation studies.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design of novel ERK5-targeted therapeutic agents.
• Inflammatory Disease Research: Applied in studies exploring ERK5's function in inflammatory responses and related pathologies.
• Cardiovascular Research: Utilized to probe the involvement of ERK5 in cardiac hypertrophy, angiogenesis, and vascular biology.
• Chemical Biology: Employed in high-throughput screening (HTS) assays and structure-activity relationship (SAR) studies for kinase profiling.

Basic Information

Product Name	Erk5-In-2
CAS No.	1888305-96-1
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	ERK5-IN-2; ERK5 Inhibitor 2; XMD8-92; 3-[(2,4-Dichlorophenyl)methyl]-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; BDBM50380895; HY-101926; XMD 8-92; MAPK7 Inhibitor
EINECS	Contact for details

Quality Control

Our Erk5-In-2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) detailing all quality parameters are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.