Description

Rorγt Inverse Agonist 6 is a potent and selective small molecule inhibitor targeting the RAR-related orphan receptor gamma t (RORγt), a key transcription factor in the differentiation and function of Th17 cells. This compound is crucial for advancing research into autoimmune and inflammatory diseases, where dysregulated Th17 cell activity is a known pathological driver. It is an essential research tool for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on immunology, drug discovery, and preclinical development.

Application

• Immunology Research: Fundamental studies on Th17 cell biology, differentiation, and cytokine production (e.g., IL-17, IL-22).
• Drug Discovery & Preclinical Development: A key reference compound and pharmacological tool for validating RORγt as a therapeutic target in new drug programs.
• Autoimmune Disease Models: Investigation of therapeutic potential in in vitro and in vivo models of diseases such as psoriasis, rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease (IBD).
• Mechanism of Action (MOA) Studies: Elucidation of signaling pathways downstream of RORγt and its role in immune regulation.
• High-Throughput Screening (HTS): Used as a control or standard in assay development and screening campaigns for identifying novel RORγt modulators.
• Biomarker Research: Exploring the correlation between RORγt inhibition and specific disease biomarkers.

Basic Information

Product Name	Rorγt Inverse Agonist 6
CAS No.	1887161-80-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	RORγt Inverse Agonist 6; ROR gamma t Inverse Agonist 6; RORgt Inverse Agonist 6; (S)-N-(4-(4-((4,4-Difluorocyclohexyl)methoxy)phenyl)thiazol-2-yl)-2-methyl-2-(methylsulfonyl)butanamide; GSK805; GSK-805; GSK 805; SR2211; SR-2211
EINECS	Contact for details

Quality Control

Every batch of Rorγt Inverse Agonist 6 CAS NO 1887161-80-9 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory submissions. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results for HPLC purity, NMR identification, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. Store away from strong acids and strong bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.