Description

Rapalink-1 CAS NO 1887095-82-0 is a potent and selective small molecule inhibitor targeting the mTOR signaling pathway, a critical regulator of cell growth and proliferation. This compound is essential for advanced biochemical research, enabling precise mechanistic studies in oncology, aging, and metabolic disorders. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics.

Application

• Biomedical Research: A key tool compound for studying mTORC1 and mTORC2 complex signaling, autophagy, and cellular metabolism in vitro and in vivo.
• Oncology Research: Used to investigate the role of mTOR in tumorigenesis, cancer cell survival, and resistance mechanisms, supporting drug discovery efforts.
• Pharmacology Studies: Employed in target validation, dose-response experiments, and combination therapy studies to assess therapeutic potential.
• Cell Biology & Signal Transduction: Facilitates the dissection of complex signaling networks involving PI3K/Akt/mTOR pathways.
• Academic & Institutional Research: Serves as a critical reagent for high-impact publications and grant-supported research in molecular biology.
• Preclinical Development: Supports pharmacokinetic/pharmacodynamic (PK/PD) modeling and efficacy testing in animal models of disease.

Basic Information

Product Name	Rapalink-1
CAS No.	1887095-82-0
Molecular Formula	C₅₆H₈₇N₅O₁₂
Molecular Weight	1030.33 g/mol
Synonyms	Rapalink-1; mTOR Inhibitor Rapalink-1; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; Third-generation mTOR inhibitor; Bifunctional mTOR inhibitor; RapaLink-1.
EINECS	Contact for details

Quality Control

Our Rapalink-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed specifications are provided to guarantee reproducibility and reliability in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.