Description

Terlipressin Diacetate Salt is a synthetic vasopressin analog, chemically defined as a modified peptide hormone. This compound is of significant commercial and therapeutic importance due to its potent and selective activity on vascular V1 receptors, offering a longer duration of action than its parent molecule. It is a critical active pharmaceutical ingredient (API) primarily required by the pharmaceutical industry for the formulation of injectable drugs used in the management of specific critical care conditions.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of finished injectable dosage forms for hospital and clinical use.
• Hepatorenal Syndrome (HRS) Treatment: Formulation into specific therapeutics indicated for the treatment of type 1 hepatorenal syndrome in adults with rapidly worsening kidney function.
• Bleeding Esophageal Varices: Used in drug products aimed at controlling bleeding from esophageal varices, a serious complication of portal hypertension.
• Vasoconstrictor Research: Serves as a key reference standard and pharmacological tool in cardiovascular and renal system research within academic and R&D institutions.
• Peptide Chemistry & Synthesis: Acts as an intermediate or building block in advanced peptide synthesis for research into new vasoactive compounds.
• GMP Manufacturing: Supplied to contract development and manufacturing organizations (CDMOs) and finished dosage formulators operating under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	Terlipressin Diacetate Salt
CAS No.	1884420-36-3
Molecular Formula	C52H74N16O15 • 2(C2H4O2)
Molecular Weight	1227.34 g/mol (for free base)
Synonyms	Terlipressin Acetate; Nα-Glycyl-glycyl-glycyl-[8-lysine]vasopressin diacetate; Triglycyl-lysine-vasopressin acetate; Glypressin (brand name); Remestyp (brand name); Terlipressinum; TP-DA
EINECS	Contact for details

Quality Control

Our Terlipressin Diacetate Salt is manufactured and tested to meet stringent pharmaceutical-grade specifications. Quality assurance protocols include identity confirmation, purity assessment, and impurity profiling using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing results for assay, related substances, residual solvents, and microbiological quality. Production can be aligned with current Good Manufacturing Practice (GMP) standards for API supply upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	< 10.0 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.