Description

Mps1-In-1 Dihydrochloride is a potent and selective small molecule inhibitor of the monopolar spindle 1 (Mps1/TTK) kinase, a key regulator of the spindle assembly checkpoint. This compound is a critical research tool for investigating cell cycle control, chromosome segregation, and mitotic fidelity in oncology and cell biology studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer therapeutics and fundamental cellular mechanisms.

Application

• Cancer Research & Drug Discovery: Used as a reference standard and pharmacological probe to study the role of Mps1 kinase in tumor cell proliferation and survival.
• Cell Biology Studies: Essential for in vitro experiments to dissect the spindle assembly checkpoint (SAC) and understand mechanisms of aneuploidy and genomic instability.
• Biochemical Assay Development: Serves as a positive control in high-throughput screening (HTS) campaigns to identify novel Mps1 inhibitors.
• Preclinical Oncology Models: Employed in cell-based and animal studies to evaluate the therapeutic potential of Mps1 inhibition for various cancer types.
• Mechanism of Action (MoA) Studies: Aids in validating target engagement and understanding downstream signaling pathways affected by Mps1 inhibition.

Basic Information

Product Name	Mps1-In-1 Dihydrochloride
CAS No.	1883548-93-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Mps1-IN-1 dihydrochloride; TTK Inhibitor Mps1-IN-1 2HCl; Monopolar spindle 1 inhibitor Mps1-IN-1 dihydrochloride; 2-[[4-[(3S)-3-Methylmorpholin-4-yl]-6-[4-(methylsulfonyl)phenyl]pyrimidin-2-yl]amino]-1,3-benzothiazole-6-carbonitrile dihydrochloride; Mps1/TTK Kinase Inhibitor (dihydrochloride)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Mps1-In-1 Dihydrochloride is characterized using advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and potency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to ensure long-term stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.