Description

4-Chloro-2,3-Difluoro-5-Methoxybenzaldehyde is a high-purity, multi-functional aromatic aldehyde building block designed for advanced synthetic chemistry. This compound is valued for its unique substitution pattern, which introduces both halogen and methoxy groups to facilitate regioselective reactions and fine-tune electronic properties in target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro and chloro substituents contribute to biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating advanced organic electronic materials, where its structure helps modulate molecular alignment and photophysical properties.
• Cross-Coupling Reactions: The aldehyde and halogen groups make it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Organic Synthesis & Scalable Production: Employed in process chemistry for the scalable, GMP-compliant production of high-value fine chemicals and custom synthesis projects.

Basic Information

Product Name	4-Chloro-2,3-Difluoro-5-Methoxybenzaldehyde
CAS No.	1879026-06-8
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	5-Methoxy-2,3-difluoro-4-chlorobenzaldehyde; 2,3-Difluoro-4-chloro-5-methoxybenzaldehyde; 4-Chloro-2,3-difluoro-5-methoxy-benzaldehyde; Benzaldehyde, 4-chloro-2,3-difluoro-5-methoxy-; 1879026-06-8
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluoro-5-Methoxybenzaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, NMR, and MS. We support cGMP and ISO compliant production for pharmaceutical applications, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.