Description

Cxcr2-In-1 CAS NO 1873376-49-8 is a potent and selective small molecule inhibitor of the C-X-C chemokine receptor type 2 (CXCR2), a key target in inflammatory and oncological research. This compound is valued for its high specificity, which enables precise modulation of the CXCR2 signaling pathway in experimental settings. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics for conditions driven by neutrophil-mediated inflammation, such as chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, and certain cancers.

Application

• Pharmacological Research: Serves as a critical tool compound for in vitro and in vivo studies investigating the role of CXCR2 in inflammatory diseases and cancer biology.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and hit-to-lead optimization campaigns to develop new anti-inflammatory or anti-cancer drug candidates.
• Biochemical Assay Development: Employed as a reference standard in developing and validating binding (e.g., radioligand) and functional assays (e.g., calcium flux, chemotaxis) for CXCR2.
• Academic & Institutional Research: Supports fundamental research into neutrophil biology, chemokine signaling networks, and the tumor microenvironment.
• Preclinical Studies: Utilized in animal models to evaluate the efficacy and pharmacokinetics of targeting the CXCR2 pathway for therapeutic intervention.

Basic Information

Product Name	Cxcr2-In-1
CAS No.	1873376-49-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CXCR2-IN-1; CXCR2 Inhibitor; 1873376-49-8; CXCR2 antagonist; Chemokine receptor CXCR2 inhibitor; (Compound name based on IUPAC nomenclature to be confirmed); Potential research code names may apply.
EINECS	Contact for details

Quality Control

Our Cxcr2-In-1 is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research purposes. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and identity confirmation. A detailed Certificate of Analysis (COA) containing specific batch data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.