Description

4-[3-(Difluoromethoxy)Phenyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One CAS NO 1858255-65-8 is a high-purity, advanced pharmaceutical intermediate belonging to the 1,2,4-triazolone class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent drug candidates, especially non-benzodiazepine anxiolytics and antipsychotics.
• Agrochemical Research: Serves as a scaffold for developing new fungicides and herbicides, leveraging the bioactivity of the triazolone moiety.
• Chemical Biology & Proteomics: Used as a specialized reagent or linker in the design of chemical probes for studying enzyme function and protein-protein interactions.
• Material Science: Investigated as a monomer or additive for creating polymers with specific thermal or optical properties.
• Academic & Industrial R&D: Employed in exploratory chemistry for the discovery of new heterocyclic compounds with potential biological activity.

Basic Information

Product Name	4-[3-(Difluoromethoxy)Phenyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One
CAS No.	1858255-65-8
Molecular Formula	C9H7F2N3O2
Molecular Weight	227.17 g/mol
Synonyms	4-(3-(Difluoromethoxy)phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 3H-1,2,4-Triazol-3-one, 4-[3-(difluoromethoxy)phenyl]-2,4-dihydro-; 4-(3-(Difluoromethoxy)phenyl)-1,2,4-triazol-5(4H)-one; DFMP-Triazolone; 1858255-65-8
EINECS	Contact for details

Quality Control

Every batch of 4-[3-(Difluoromethoxy)Phenyl]-2,4-Dihydro-3H-1,2,4-Triazol-3-One is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, identity, and impurity profiles verified by HPLC, NMR, and MS. Our quality assurance protocols are designed to meet the stringent requirements of cGMP for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.