Description

Btk Inhibitor 17 CAS NO 1858206-76-4 is a potent and selective small molecule inhibitor of Bruton's Tyrosine Kinase (BTK), a key enzyme in the B-cell receptor signaling pathway. This compound is a critical research tool for investigating B-cell malignancies, autoimmune disorders, and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Biochemical Research: Used as a reference standard and pharmacological tool to study BTK signaling mechanisms and validate assay systems.
• Drug Discovery & Development: Serves as a lead compound or positive control in high-throughput screening (HTS) campaigns for novel BTK inhibitors.
• Oncology Research: Investigated in cellular and animal models of B-cell lymphomas, leukemias, and other hematological cancers.
• Autoimmune Disease Research: Applied in studies targeting conditions like rheumatoid arthritis, lupus, and multiple sclerosis where BTK plays a role.
• Inflammation Studies: Used to elucidate the role of BTK in immune cell activation and inflammatory responses.
• Mechanism of Action (MoA) Studies: Essential for understanding drug resistance and combination therapy strategies in targeted cancer treatments.

Basic Information

Product Name	Btk Inhibitor 17
CAS No.	1858206-76-4
Molecular Formula	C₂₉H₃₀N₈O₂
Molecular Weight	522.61 g/mol
Synonyms	Btk Inhibitor 17; 6-Cyclopropyl-8-fluoro-2-[(2S)-1-hydroxy-3-methylbutan-2-yl]-1,4-dihydro-4-(4-methoxyphenyl)pyrido[2,3-d]pyrimidin-7-one; 6-Cyclopropyl-8-fluoro-2-[(2S)-1-hydroxy-3-methylbutan-2-yl]-1-methyl-4-(4-methoxyphenyl)-1,4-dihydroquinazolin-7-one; GNE-274; GNE 274; BTK Inhibitor GNE-274; (S)-6-Cyclopropyl-8-fluoro-2-(1-hydroxy-3-methylbutan-2-yl)-1-methyl-4-(4-methoxyphenyl)-1,4-dihydroquinazolin-7-one
EINECS	Contact for details

Quality Control

Our Btk Inhibitor 17 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container should be sealed under dry conditions and allowed to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.