Description

Chloroquine D5 is a deuterated analog of the well-known antimalarial and immunomodulatory agent, chloroquine. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical research. It is a critical tool for scientists and quality control professionals in the pharmaceutical, clinical research, and forensic toxicology industries who require precise measurement of chloroquine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for drug level monitoring.

• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of chloroquine absorption, distribution, metabolism, and excretion (ADME) in biological matrices.

• Pharmaceutical Quality Control: Used in the assay and impurity profiling of chloroquine-based drug products to ensure batch-to-batch consistency.

• Clinical Research: Supports therapeutic drug monitoring (TDM) and bioequivalence studies for chloroquine and hydroxychloroquine.

• Forensic and Toxicology Analysis: Provides definitive quantification in cases of overdose or post-mortem investigations.

• **| Item | Details |
  | --- | --- |
  | Product Name | Chloroquine D5 |
  | CAS No. | 1854126-41-2 |
  | Molecular Formula | C18H21D5ClN3 |
  | Molecular Weight | Contact for details |
  | Synonyms | Chloroquine-d5; 7-Chloro-4-[[4-(diethylamino-d5)-1-methylbutyl]amino]quinoline; N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-d5-pentane-1,4-diamine; Deuterochloroquine; Chloroquine (diethyl-d5); Stable Isotope Labeled Chloroquine |
  | EINECS | Contact for details |

  Quality Control

  Our Chloroquine D5 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity, and residual solvents. We adhere to relevant industry standards for reference materials, and custom synthesis to meet specific pharmacopeial or client specifications is available.

  Storage

  Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

  Specification

  Item	Specification
  Appearance	White to off-white solid
  Identification (HPLC/MS)	Conforms
  Purity (HPLC)	≥ 98.0%
  Isotopic Purity (D-content)	≥ 98 atom % D
  Water Content (KF)	≤ 0.5%
  Residual Solvents (GC)	Meets ICH guidelines

  Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.**