Description

n-[2R-Hydroxy-1S-(Hydroxymethyl)-3E-Heptadecen-1-Yl-D7]-Hexadecanamide is a high-purity, deuterium-labeled ceramide analog, a critical tool compound for advanced biochemical and pharmaceutical research. Its primary value lies in its use as a stable, isotopically labeled internal standard for the precise quantification of natural ceramides via mass spectrometry, ensuring superior analytical accuracy and reproducibility. This compound is essential for researchers and quality control laboratories in the pharmaceutical, dermatological, and lipidomics fields who require definitive standards for metabolic pathway studies, biomarker discovery, and formulation analysis.

Application

• Mass Spectrometry Internal Standard: Serves as a deuterium-labeled (D7) reference standard for the accurate LC-MS/MS quantification of endogenous ceramides and related sphingolipids in complex biological matrices.
• Lipidomics Research: A vital tool for investigating sphingolipid metabolism, signaling pathways, and their roles in cellular processes like apoptosis, proliferation, and stress response.
• Pharmaceutical R&D: Used in the development and validation of bioanalytical methods for drug candidates targeting ceramide-related pathways in oncology, dermatology, and metabolic diseases.
• Dermatological Product Testing: Enables precise measurement of ceramide levels in skin barrier function studies and the quality control of topical formulations designed for skin repair.
• Biomarker Discovery & Validation: Facilitates the identification and quantification of ceramide species as potential diagnostic or prognostic biomarkers in clinical research.
• Metabolic Flux Analysis: Employed in tracer studies to elucidate the dynamics of sphingolipid synthesis and turnover in cell culture and animal models.

Basic Information

Product Name	n-[2R-Hydroxy-1S-(Hydroxymethyl)-3E-Heptadecen-1-Yl-D7]-Hexadecanamide
CAS No.	1840942-13-3
Molecular Formula	C34H60D7NO3
Molecular Weight	~ 546.9 g/mol
Synonyms	Ceramide(d7) Standard; N-[(2R,3E)-2-Hydroxy-1-(hydroxymethyl-d2)-3-heptadecen-1-yl-d5]hexadecanamide; Deuterated Ceramide (d7); Hexadecanamide, N-[(2R,3E)-2-hydroxy-1-(hydroxymethyl-d2)-3-heptadecen-1-yl-d5]-; Ceramide (d18:1-d7/16:0); Stable Isotope-Labeled Ceramide; Internal Standard Ceramide-d7; N-Palmitoyl-D-erythro-sphingosine-d7.
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity, critical for trace-level analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and high-resolution mass spectrometry to confirm structure, isotopic enrichment (>98 atom % D), and chemical purity (typically ≥95% by HPLC). Comprehensive Certificates of Analysis (COA) detailing all analytical results are provided to support your research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.