Description

E3 Ligase Ligand-Linker Conjugates 11 is a high-purity, synthetic chemical building block designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) modalities. This compound is critical for researchers and pharmaceutical developers aiming to create novel therapeutics by hijacking the cell's natural ubiquitin-proteasome system to degrade disease-causing proteins. It is primarily utilized in pre-clinical research, drug discovery, and medicinal chemistry within the biopharmaceutical and life sciences sectors.

Application

• PROTAC Molecule Synthesis: Serves as a key component for constructing heterobifunctional PROTAC molecules that link an E3 ligase ligand to a protein-of-interest (POI) binder.
• Targeted Protein Degradation Research: Enables the study of novel degradation pathways and the validation of new therapeutic targets in cellular and in-vivo models.
• Chemical Biology Tool Development: Used to create probes for investigating E3 ligase function, substrate specificity, and ubiquitination dynamics.
• Medicinal Chemistry Optimization: Acts as a starting material or intermediate for optimizing the linker length, composition, and physicochemical properties of TPD candidates.
• Biopharmaceutical R&D: Supports early-stage drug discovery programs focused on oncology, neurodegenerative diseases, and other conditions with undruggable targets.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 11
CAS No.	1835705-61-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker Conjugate 11; E3 Ligase Ligand-Linker 11; TPD Building Block 11; (S,R,S)-AHPC-PEG3-C2-Cl; VHL Ligand-Linker Conjugates 11; Cereblon/DDB1-based Molecular Glue Derivative; Ubiquitin-Proteasome System Modulator; Targeted Degradation Compound
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 11 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable for non-GMP materials, ensuring traceability and documentation suitable for pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.