Description

E3 Ligase Ligand-Linker Conjugates 9 is a high-purity, synthetic chemical building block specifically designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation (TPD) modalities. This compound matters as a critical component for researchers and developers aiming to create novel therapeutics by hijacking the cell's natural ubiquitin-proteasome system to degrade disease-causing proteins. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on oncology, neurodegenerative diseases, and other challenging therapeutic areas where traditional inhibition is insufficient.

Application

• PROTAC Molecule Synthesis: Serves as a key ligand-linker component for constructing heterobifunctional PROTAC degraders.
• Targeted Protein Degradation Research: Used in the development and optimization of novel degrader platforms for undruggable targets.
• Chemical Biology Tool Development: Incorporated into probes for studying E3 ligase engagement, ubiquitination, and protein turnover.
• Preclinical Drug Discovery: A vital intermediate in the medicinal chemistry pipeline for evaluating degradation efficacy, selectivity, and pharmacokinetics.
• Bioconjugation: The reactive linker moiety allows for conjugation to various warheads targeting proteins of interest (POIs).
• Library Synthesis: Enables the rapid generation of diverse PROTAC libraries for high-throughput screening campaigns.

Basic Information

Product Name	E3 Ligase Ligand-Linker Conjugates 9
CAS No.	1835705-59-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker 9; E3 Ligase Ligand Conjugate 9; VHL Ligand-Linker Conjugate 9 (based on common structural motifs); (2S,4R)-1-((S)-2-(2-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)acetyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (Possible IUPAC); Degrader Building Block 9; TPD Linker-Ligand 9; Cereblon/VHL Recruiting Moiety 9
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 9 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.