Description

n-Me-Auristatin / Monomethylauristatin is a highly potent synthetic derivative of the natural marine cytotoxin dolastatin 10, designed for targeted therapeutic applications. Its core value lies in its function as a microtubule-disrupting payload in Antibody-Drug Conjugates (ADCs), enabling the precise delivery of cytotoxic agents to cancer cells while minimizing systemic toxicity. This compound is critically needed by pharmaceutical R&D teams, biotech companies, and contract manufacturing organizations (CMOs) engaged in the development of next-generation oncology therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the primary cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a key reference standard and active component in preclinical studies for evaluating antitumor efficacy and mechanism of action.
• Bioconjugation Chemistry Development: Employed in the research and optimization of novel linker technologies for stable and cleavable ADC constructs.
• Process Development & Scale-up: Critical material for developing and validating GMP-compatible synthesis and purification processes for clinical-stage ADCs.
• Potency Assay Standard: Acts as a calibrated standard in bioanalytical assays to determine the drug-to-antibody ratio (DAR) and overall conjugate potency.

Basic Information

Product Name	n-Me-Auristatin / Monomethylauristatin
CAS No.	1835700-39-4
Molecular Formula	C39H67N5O7
Molecular Weight	718.0 g/mol (approximately)
Synonyms	Monomethylauristatin E; MMAE; N-Me-Auristatin E; Auristatin E Methyl Ester; (3S,4S,7S,10S,16S,19S,22S,28S,31S)-31-[(1S)-1-Methoxy-2-methyl-1-oxo-2-propen-1-yl]-4,10,22,28-tetramethyl-7,19-bis(1-methylethyl)-3,16-di(1-oxopropoxy)-1,2,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,28,29,30,31,32,33,34,35-dotriacontahydro-14,18-methano-1H,17H-2,8:21,26-dietheno-13,7:20,24-dimethenodipyrrolo[2,3-h:2',3'-l][1,9,5,15]dioxadiazacyclodocosine-1,17(2H,18H)-dione
EINECS	Contact for details

Quality Control

Our n-Me-Auristatin / Monomethylauristatin is manufactured under strict quality systems to ensure the high purity and consistency required for critical pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support regulatory filings (IND, NDA).

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is strictly light-sensitive (protect from all light exposure) and hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.