Description

(R)-4-Phenyl-2-(5-(Trifluoromethyl)Pyridin-2-Yl)-4,5-Dihydrooxazole is a high-value chiral oxazoline derivative, a critical building block in modern asymmetric synthesis and pharmaceutical development. Its core value lies in its role as a versatile ligand precursor and a key intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, enantiomerically pure intermediates for catalysis and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Catalysis Ligand Precursor: Serves as a precursor for chiral oxazoline ligands used in transition metal-catalyzed reactions like asymmetric hydrogenation, cyclopropanation, and Diels-Alder reactions.
• Agrochemical Research: Used in the synthesis of enantiomerically pure active ingredients for herbicides, fungicides, and insecticides, enhancing efficacy and reducing environmental impact.
• Material Science: Employed in the development of chiral polymers and liquid crystals with specific optical properties.
• Academic & Process Chemistry: A valuable tool for methodology development in organic synthesis and for scaling up enantioselective processes.

Basic Information

Item	Details
Product Name	(R)-4-Phenyl-2-(5-(Trifluoromethyl)Pyridin-2-Yl)-4,5-Dihydrooxazole
CAS No.	1835671-08-3
Molecular Formula	C15H11F3N2O
Molecular Weight	292.26 g/mol
Synonyms	(R)-4-Phenyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole; (R)-2-(5-(Trifluoromethyl)pyridin-2-yl)-4-phenyl-4,5-dihydrooxazole; (R)-4-Phenyl-2-(5-trifluoromethyl-2-pyridyl)-2-oxazoline; (R)-4,5-Dihydro-4-phenyl-2-[5-(trifluoromethyl)-2-pyridinyl]oxazole; (R)-Oxazoline ligand precursor; (R)-CF3-PyOx
EINECS	Contact for details

Quality Control

Our (R)-4-Phenyl-2-(5-(Trifluoromethyl)Pyridin-2-Yl)-4,5-Dihydrooxazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) verification, NMR, and LC-MS for identity and purity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.