Description

Pan-Ras-In-1 is a potent and selective small molecule inhibitor designed to target the pan-Ras family of proteins. This compound is a critical research tool for investigating Ras-driven signaling pathways, which are implicated in a significant percentage of human cancers. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology drug discovery and molecular biology.

Application

• Oncology Research & Drug Discovery: A key biochemical tool for studying Ras-mediated oncogenesis and validating Ras as a therapeutic target in various cancer cell lines and models.
• Signal Transduction Studies: Used to elucidate the role of Ras proteins (H-Ras, K-Ras, N-Ras) in critical cellular processes like proliferation, differentiation, and survival.
• High-Throughput Screening (HTS): Serves as a reference standard or positive control in assays designed to identify novel Ras pathway inhibitors.
• Preclinical Development: Supports in vitro and in vivo pharmacokinetic/pharmacodynamic (PK/PD) studies for anti-cancer candidate compounds.
• Mechanism of Action (MoA) Analysis: Essential for confirming the specificity and efficacy of new therapeutic agents targeting the Ras/MAPK pathway.
• Academic & Institutional Research: Facilitates fundamental research in cell biology, biochemistry, and genetics related to GTPase function.

Basic Information

Product Name	Pan-Ras-In-1
CAS No.	1835283-94-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.42 g/mol
Synonyms	Pan-Ras inhibitor 1; 2-(2,5-Dimethoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine; (S)-2-(2,5-Dimethoxyphenyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine; Pan Ras Inhibitor; Pan-Ras-In-1 (CAS 1835283-94-7)
EINECS	Contact for details

Quality Control

Our Pan-Ras-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.